Am J Clin Exp Obstet Gynecol 2013;1(1):69-75
Case Report
Hypersensitivity reaction to parenteral nutrition after severe
hypersensitivity reaction to paclitaxel: a case report
Janiel M Cragun, Jennifer H Baggs, Carol Rollins, Setsuko K Chambers
Department of Obstetrics and Gynecology, University of Arizona, University of Arizona Cancer Center, Tucson, AZ, USA;
Department of Pharmacy, University of Arizona Medical Center, Tucson, AZ, USA; Department of Pharmacy Practice
and Science, University of Arizona, Tucson, AZ, USA
Received October 14, 2013; Accepted November 10, 2013; Epub December 7, 2013; Published December 15, 2013
Abstract: Paclitaxel, an anti-microtubule chemotherapeutic agent, is known for hypersensitivity reactions.
Hypersensitivity reactions associated with paclitaxel may be secondary to its vehicle, Cremophor EL rather than the
paclitaxel itself. In contrast, hypersensitivity reactions to parenteral nutrition are uncommon. Both the lipid component
and multivitamin have been implicated in hypersensitivity reactions to parenteral nutrition. Similar to paclitaxel, the
vehicle for IV vitamins, polysorbate 80, may be the source of reaction rather than the vitamin, itself. We present a case
report of a patient who had a severe hypersensitivity reaction to paclitaxel and also a hypersensitivity reaction to the
multivitamin component of parenteral nutrition, as well as to vitamin K administered separate from parenteral
nutrition. To our knowledge this is the first case report describing a potential cross-hypersensitivity to these agents.
(AJCEOG1310004).
Keywords: Hypersensitivity, parenteral nutrition, paclitaxel
Address correspondence to: Dr. Janiel M Cragun, Department of Obstetrics and Gynecology, University of Arizona,
University of Arizona Cancer Center, 1515 N. Campbell Avenue, PO Box 245024, Tucson, AZ 85724, USA. Fax:
520-694-9287; E-mail: Janiel.Cragun@uahealth.com
Case Report
Hypersensitivity reaction to parenteral nutrition after severe
hypersensitivity reaction to paclitaxel: a case report
Janiel M Cragun, Jennifer H Baggs, Carol Rollins, Setsuko K Chambers
Department of Obstetrics and Gynecology, University of Arizona, University of Arizona Cancer Center, Tucson, AZ, USA;
Department of Pharmacy, University of Arizona Medical Center, Tucson, AZ, USA; Department of Pharmacy Practice
and Science, University of Arizona, Tucson, AZ, USA
Received October 14, 2013; Accepted November 10, 2013; Epub December 7, 2013; Published December 15, 2013
Abstract: Paclitaxel, an anti-microtubule chemotherapeutic agent, is known for hypersensitivity reactions.
Hypersensitivity reactions associated with paclitaxel may be secondary to its vehicle, Cremophor EL rather than the
paclitaxel itself. In contrast, hypersensitivity reactions to parenteral nutrition are uncommon. Both the lipid component
and multivitamin have been implicated in hypersensitivity reactions to parenteral nutrition. Similar to paclitaxel, the
vehicle for IV vitamins, polysorbate 80, may be the source of reaction rather than the vitamin, itself. We present a case
report of a patient who had a severe hypersensitivity reaction to paclitaxel and also a hypersensitivity reaction to the
multivitamin component of parenteral nutrition, as well as to vitamin K administered separate from parenteral
nutrition. To our knowledge this is the first case report describing a potential cross-hypersensitivity to these agents.
(AJCEOG1310004).
Keywords: Hypersensitivity, parenteral nutrition, paclitaxel
Address correspondence to: Dr. Janiel M Cragun, Department of Obstetrics and Gynecology, University of Arizona,
University of Arizona Cancer Center, 1515 N. Campbell Avenue, PO Box 245024, Tucson, AZ 85724, USA. Fax:
520-694-9287; E-mail: Janiel.Cragun@uahealth.com
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