Am J Clin Exp Obstet Gynecol 2013;1(1):31-36
Review Article
Tubal origin of ovarian low-grade serous carcinoma
Chenglu Chen, Jie Li, Guang Yao, Setsuko K Chambers, Wenxin Zheng
Department of Molecular and Cellular Biology, University of Arizona, Tucson, AZ, USA; Department of Obstetrics and
Gynecology, University of Arizona, Tucson, AZ, USA; Department of Pathology, University of Arizona College of
Medicine, Tucson, AZ, USA; Department of Obstetrics and Gynecology, Qilu Hospital, Shandong University, Shandong,
China; Arizona Cancer Center, University of Arizona, Tucson, AZ, USA
Received October 2, 2013; Accepted November 10, 2013; Epub December 7, 2013; Published December 15, 2013
Abstract: Our understanding of the carcinogenesis and histogenesis of ovarian cancer has undergone a paradigm
shift in recent years, after accumulating evidence from morphologic and molecular genetic studies. Findings from
these studies suggest that both high-grade and low-grade serous ovarian cancers, traditionally believed to start from
the ovarian surface, may originate from the distal fallopian tube. This article reviews recent evidence for the tubal
origin of serous ovarian cancers, especially the low-grade serous carcinomas. (AJCEOG1310001).
Keywords: Ovarian cancer, serous carcinoma, fallopian tube, cell of origin
Address correspondence to: Guang Yao, Department of Molecular and Cellular Biology, University of Arizona,
Tucson, AZ, USA. E-mail: guangyao@arizona.edu
Review Article
Tubal origin of ovarian low-grade serous carcinoma
Chenglu Chen, Jie Li, Guang Yao, Setsuko K Chambers, Wenxin Zheng
Department of Molecular and Cellular Biology, University of Arizona, Tucson, AZ, USA; Department of Obstetrics and
Gynecology, University of Arizona, Tucson, AZ, USA; Department of Pathology, University of Arizona College of
Medicine, Tucson, AZ, USA; Department of Obstetrics and Gynecology, Qilu Hospital, Shandong University, Shandong,
China; Arizona Cancer Center, University of Arizona, Tucson, AZ, USA
Received October 2, 2013; Accepted November 10, 2013; Epub December 7, 2013; Published December 15, 2013
Abstract: Our understanding of the carcinogenesis and histogenesis of ovarian cancer has undergone a paradigm
shift in recent years, after accumulating evidence from morphologic and molecular genetic studies. Findings from
these studies suggest that both high-grade and low-grade serous ovarian cancers, traditionally believed to start from
the ovarian surface, may originate from the distal fallopian tube. This article reviews recent evidence for the tubal
origin of serous ovarian cancers, especially the low-grade serous carcinomas. (AJCEOG1310001).
Keywords: Ovarian cancer, serous carcinoma, fallopian tube, cell of origin
Address correspondence to: Guang Yao, Department of Molecular and Cellular Biology, University of Arizona,
Tucson, AZ, USA. E-mail: guangyao@arizona.edu
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